The Advantages of AdvantaFlex

AdvantaFlex, an AdvantaPure thermoplastic elastomer (TPE) tubing, offers numerous benefits in biopharmaceutical applications due to its unique properties and advanced formulation. Here are some of the key advantages of using AdvantaFlex:

 

• Biocompatibility: AdvantaFlex is biocompatible, making it suitable for various applications. It meets stringent regulatory standards, which can be found here, ensuring it is safe for sensitive applications.

• Serializability: AdvantaFlex can withstand various sterilization methods, such as gamma radiation and autoclaving. This makes it ideal for single-use applications where sterility is required.

• Flexibility and Softness: AdvantaFlex combines rubber’s elasticity with plastics’ processability. Its flexibility and softness make it suitable for applications like tubing and overmolding, where a soft touch is preferable.

• Chemical Resistance: AdvantaFlex exhibits excellent resistance to a wide range of chemicals, including many solvents and oils. This is crucial in biopharmaceutical environments where contact with various chemicals is common. Learn more about chemical compatibility here.

• Translucency: AdvantaFlex is naturally translucent, which is advantageous for applications requiring visual inspection of the fluid.

• Low Extractables and Leachables: AdvantaFlex is formulated to minimize extractables and leachables, ensuring the purity and safety of biopharmaceutical products. Our comprehensive validation guide includes a full BPOG testing report, which you can request a copy of here.

• Processability: AdvantaFlex can be processed using conventional thermoplastic manufacturing techniques and equipment. This makes it a versatile and cost-effective material for producing parts used in a variety of biopharmaceutical applications.

• Lower Absorption: With less permeability than silicone, AdvantaFlex may have a lower absorption to chemicals commonly used in bioprocessing, making it a better choice for certain manufacturing processes.

 
AdvantaFlex by AdvantaPure is a valuable material in the biopharmaceutical industry. It contributes to the development of safe, effective, and reliable products. Its biocompatibility, flexibility, chemical resistance, and processability make it an ideal choice for a wide range of applications.
 
If you wish to talk about AdvantaFlex as a solution to your fluid transfer needs with someone from our team phone us at 800-506-3924 or +1-215-526-2300,
e-mail info@newageindustries.com,
or use the Contact Us form below.

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Introduction

In the world of bioprocessing, maintaining a clean and sterile environment is paramount to ensuring the safety and quality of the final product. While rigorous cleaning protocols are often in place, the floor is one overlooked aspect of contamination control. Surprising as it may seem, the floor can be the dirtiest part of an otherwise clean room. In this blog post, we will explore how contaminants can flow from the floor to your tubing and, ultimately, to your product in a bioprocess. We will also emphasize the vital role of Hose Holders in keeping tubing off the floor and maintaining the integrity of your bioprocessing system.

Understanding Floor Contamination

The floor can accumulate a range of contaminants, including dust, dirt, bacteria, and even chemical residues. These contaminants can find their way into a bioprocessing environment, posing a significant risk to product quality and safety.

Contamination Pathways

One critical pathway through which floor contaminants can infiltrate a bioprocess is via tubing. Tubing often runs along or near the floor, making it susceptible to contact with floor-borne contaminants. Any breach in the tubing, such as cracks, leaks, or even simple contact, can allow contaminants to enter the system. Once inside, these contaminants can travel along the tubing and potentially reach the product, compromising its purity and integrity.  In addition, touching tubing that sits on the floor and not changing gloves after could also lead to contamination of the product.

The Role of Hose Holders

Hose holders play a vital role in preventing floor contamination in bioprocessing environments. This simple yet effective device provides a solution for keeping tubing elevated, preventing it from coming into contact with the floor. Hose Holders are made from high-density polyethylene that is easy to clean and sterilize.

Benefits of Using Hose Holders

1. Contamination Prevention:

By keeping tubing off the floor, hose holders act as a physical barrier, preventing floor contaminants from making direct contact with the tubing. This significantly reduces the risk of contamination and helps maintain the integrity of the bioprocess.

2. Easy Cleaning and Maintenance:

Hose holders are designed to be easily detachable and cleanable, making them convenient for regular cleaning and maintenance routines. This ensures that the holders themselves do not become potential sources of contamination.

3. Organized Tubing Layout:

In addition to contamination control, Hose Holders help create an organized tubing layout. Properly supported tubing prevents tangling, kinking, or accidental disconnections, improving the overall efficiency and reliability of the bioprocessing system.

Conclusion

In bioprocessing, every precaution must be taken to ensure the purity and safety of the final product. While many aspects of contamination control are well-addressed, the floor often goes unnoticed as a potential source of contaminants. Understanding the pathways through which floor contaminants can infiltrate your bioprocess is crucial for maintaining product integrity.

Hose holders provide a practical and effective solution to keep tubing elevated, preventing direct contact with the floor and minimizing the risk of contamination. By incorporating Hose Holders into your bioprocessing setup, you not only safeguard the quality of your product but also promote a clean and organized working environment.

Remember, in the world of bioprocessing, even the smallest preventive measures can have a significant impact on the success and safety of your operations. So, don’t underestimate the power of a hose holder in keeping your bioprocess clean and contamination-free.

If you wish to talk about solutions with someone from our team phone us at 800-506-3924 or +1-215-526-2300,
e-mail info@newageindustries.com,
or use the Contact Us form below.

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The white paper, titled ” Preventing Kinking in Tubing: Strategies for Reliable Fluid Transfer,” delves into the multifaceted nature of kinking prevention. By examining factors such as material properties, bend radius, tube diameter, wall thickness, and external forces, engineers, manufacturers, and operators are guided in implementing strategies that ensure tubing functions optimally.

Industries ranging from medical and industrial to aerospace and fluid transfer systems are impacted by kinked tubing. Partial or complete blockages caused by excessive bending can disrupt vital processes. Industrial environments may face equipment malfunctions and production interruptions, while the aviation sector’s safety and control can be compromised due to kinks in hydraulic or fuel lines. Diminished flow rates, pressure drops, and material stress are additional risks that can lead to premature wear, leaks, and compromised product quality.

NewAge Industries, a trusted industry leader with over two decades of tubing expertise, emphasizes the importance of a strong partnership to combat tubing kinking. The company’s ISO 9001 certification and skilled team of engineers and technicians ensure the selection of appropriate tubing and proper installation. With an extensive array of tubing products and services, including customized solutions, NewAge Industries offers a holistic approach to tubing needs.

The white paper serves as a valuable resource for those seeking to prevent tubing kinking and prioritize system efficiency and safety. By partnering with experts and implementing proven strategies, industries can overcome the challenges posed by tubing kinks and ensure the dependability of critical applications.

For more information or to access the white paper, visit https://shorturl.at/aclyF, email info@newageindustries.com or call us at 215-526-2151.

About NewAge Industries:

In business since 1954, NewAge Industries manufactures plastic and rubber tubing in reinforced and unreinforced styles. The company maintains a large inventory of tubing and fittings for its core product lines, provides custom extrusion and fabrication capabilities, and services customers worldwide. The AdvantaPure ® division of NewAge Industries specializes in high purity tubing, hose, single-use process tubing manifolds, AdvantaFlex® TPE tubing, AdvantaSil® silicone tubing and hose, BioClosure® container closure systems, and other molded components for the pharmaceutical and biopharma industries. Products are manufactured, stored, and shipped using methods that ensure product purity. Automated product identification systems, including gamma stable RFID tags and labels, are offered by NewAge’s Verigenics® division. Additionally, NewAge Industries is proud to be ISO 9001 certified, demonstrating our commitment to quality and continuous improvement.

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AdvantaFlex®, AdvantaSil®, BioClosure®, NewAge®, NewAge Industries AdvantaPure®, and Verigenics® are registered trademarks of NewAge® Industries, Inc.

The post Press Release: New White Paper Reveals Strategies to Prevent Tubing Kinking and Ensure Fluid Transfer Efficiency appeared first on NewAge Industries.

 
In today’s fast-paced industrial landscape, efficient thermal management is essential for the optimal performance and longevity of machinery and equipment. Overheating can lead to reduced efficiency, increased maintenance costs, and even catastrophic failures. To combat this challenge, industries are continually seeking innovative solutions, and one material that has gained prominence in the quest for better thermal management is silicone tubing.

Silicone tubing is a versatile and reliable material that has found applications in a wide range of industries. Its unique properties make it an ideal choice for addressing thermal management issues, and in this blog post, we will explore the various ways silicone tubing can help improve thermal management across different sectors.
 

Understanding the Importance of Thermal Management

 
Thermal management involves the control and regulation of temperature within systems and equipment to maintain them within safe operating limits. Inadequate thermal management can result in:
 

• Reduced Efficiency: Overheating can cause electronic components to operate less efficiently, leading to performance degradation and increased power consumption.

• Shortened Lifespan: Excessive heat accelerates wear and tear, reducing the lifespan of machinery and equipment.

• Costly Repairs and Downtime: Frequent overheating-related failures can lead to unplanned downtime, resulting in production delays and increased maintenance costs.

• Safety Concerns: In some industries, such as automotive, inadequate thermal management can pose safety risks.
 

Silicone Tubing: A Thermal Management Solution

 
Silicone tubing is a flexible and heat-resistant material made from silicone rubber, which offers a range of properties that make it an ideal choice for thermal management applications. Let’s delve into how silicone tubing can address thermal management challenges in various industries.
 

Electronics Industry

 
In the electronics industry, managing heat is crucial for the reliable operation of electronic components. Silicone tubing offers several advantages in this regard:
 

• Heat Resistance: Silicone tubing can withstand high temperatures, making it suitable for applications near heat sources like CPUs, power supplies, and LED lighting.

• Flexibility and Conformability: Its flexibility allows it to conform to various shapes and sizes, making it easy to route coolant or airflow to heat-sensitive components.

• Insulation Properties: Silicone tubing has excellent electrical insulation properties, preventing electrical shorts and enhancing safety.

• Chemical Resistance: It is resistant to many chemicals commonly used in electronic cooling systems, ensuring long-term durability.

• Low Thermal Conductivity: Silicone has low thermal conductivity, helping to maintain temperature gradients and reduce heat transfer.
 

Automotive Industry

 
In the automotive industry, managing heat generated by engines, exhaust systems, and electronic components is essential for vehicle performance and safety. Silicone tubing plays a vital role in several aspects of thermal management:
 

• Coolant Systems: Silicone tubing is commonly used in coolant systems to transfer hot coolant from the engine to the radiator. Its heat resistance and durability are crucial in this demanding environment.

• Air Intake Systems: Silicone tubing is employed in air intake systems to withstand high underhood temperatures, ensuring efficient engine performance.

• Exhaust Systems: For turbocharged engines, silicone tubing can handle the heat generated in the exhaust system while maintaining its structural integrity.

• Electrical Systems: In electric and hybrid vehicles, silicone tubing is used to protect and insulate high-voltage wiring, ensuring safety and preventing overheating.
 

Medical and Pharmaceutical Industries

Precision and reliability are paramount in the medical and pharmaceutical sectors, where maintaining the correct temperature is essential for the safety and efficacy of products and processes. Silicone tubing contributes to thermal management in several ways:

• Fluid Transfer: Silicone tubing is used for the transfer of temperature-sensitive fluids and reagents in laboratories and pharmaceutical manufacturing.

• Peristaltic Pumps: Its flexibility and biocompatibility make silicone tubing ideal for use in peristaltic pumps, which are commonly employed for fluid handling in medical devices.

• Sterilization: Silicone tubing can withstand high-temperature sterilization processes, ensuring that medical equipment and devices remain safe for use.

• Chemical Compatibility: It is resistant to a wide range of chemicals, ensuring that it doesn’t react with or contaminate sensitive substances.

Food and Beverage Industry

In the food and beverage industry, maintaining proper temperature control is critical to preserving product quality and safety. Silicone tubing is widely used for thermal management in this sector:

• Heat Exchangers: Silicone tubing is employed in heat exchangers to transfer heat efficiently during processes such as pasteurization and sterilization.

• Brewing and Winemaking: It is used in temperature control systems for fermenters, ensuring precise fermentation conditions.

• Liquid Transfer: Silicone tubing is used to transfer hot or cold liquids without affecting their taste or quality, making it suitable for beverage production.

• Hygienic Design: Silicone tubing meets stringent hygiene standards and is easy to clean, reducing the risk of contamination.

Industrial Automation and Machinery

In industrial settings, the efficient operation of machinery is crucial for productivity. Silicone tubing can aid in thermal management in this context:

• Cooling Systems: Silicone tubing is used in cooling systems for machinery, ensuring that critical components stay within safe operating temperatures.

• Hydraulic Systems: It is employed in hydraulic systems to transfer hydraulic fluids, which can generate heat during operation.

• Material Handling: In manufacturing, silicone tubing can transport hot materials without warping or degrading, contributing to process efficiency.

• Chemical Resistance: Silicone tubing’s chemical resistance is valuable in industries where exposure to corrosive substances is a concern.
 

Conclusion

 
Efficient thermal management is a critical consideration in numerous industries, where overheating can lead to reduced efficiency, increased maintenance costs, and even safety hazards. Silicone tubing emerges as a versatile and reliable solution to address these challenges across a wide range of applications.
 
Its unique combination of heat resistance, flexibility, chemical compatibility, and electrical insulation properties makes silicone tubing an ideal choice for thermal management tasks in the electronics, automotive, medical, food and beverage, and industrial sectors. By incorporating silicone tubing into their systems and processes, industries can enhance efficiency, reliability, and safety while extending the lifespan of equipment and machinery.
 
As technology continues to advance and industries evolve, silicone tubing will likely remain at the forefront of thermal management solutions, helping industries meet the ever-increasing demands for performance and reliability in a wide array of applications.
 
If you wish to talk about solutions to your thermal management issues with someone from our team phone us at 800-506-3924 or +1-215-526-2300,
e-mail info@newageindustries.com,
or use the Contact Us form below.

The post Enhancing Thermal Management in Various Industries with Silicone Tubing appeared first on NewAge Industries.

• Avoid sharp bends; opt for gradual, smooth bends with the right bending radius, following the tubing manufacturer’s recommendations. Consider using a bending spring or tube bender for precision.

• When changing direction, use elbow fittings instead of forcing sharp turns. Elbows help preserve tubing integrity and reduce the risk of kinking.

• Do not exceed the tubing’s recommended limits, as overstretching can create stress points and lead to kinking.

• Provide enough slack in the tubing to accommodate movement and system changes without tension. However, avoid excessive slack that may cause sagging.

• Use clamps, brackets, or other fixtures to securely support the tubing’s route, preventing accidental compression or damage.

• Inspect the tubing regularly for signs of kinking, wear, or damage. Replace any compromised tubing to maintain system integrity.

Following these tips can help you avoid tubing kinks and keep your system running smoothly.

To gain a more in-depth understanding of this topic, including insights into external factors that can cause your tubing to kink, studies, and more, be sure to grab your free copy of our most recent white paper!

White Papers & Case Studies

If you wish to talk about solutions with someone from our team phone us at 800-506-3924 or +1-215-526-2300,
e-mail info@newageindustries.com,
or use the Contact Us form below.

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As the world transitions towards a more sustainable future, electric vehicles (EVs) are at the forefront of this transformative shift. The benefits of EVs are evident, from reducing greenhouse gas emissions to lowering our dependence on fossil fuels. However, there’s a critical challenge that electric vehicle manufacturers must address – thermal management for EV batteries. Effective thermal management is essential to ensure the safety, performance, and longevity of EV batteries. In this blog post, we will explore the significance of thermal management in EV batteries and how silicone tubing can play a crucial role in addressing this issue.

The Importance of Thermal Management in EV Batteries

Electric vehicle batteries are the heart of the vehicle’s powertrain. They store and supply energy to the electric motor, enabling the vehicle to move. However, during charging and discharging, these batteries generate heat. This heat can have detrimental effects on the battery’s performance and overall safety if not managed effectively. Here are some of the key reasons why thermal management in EV batteries is of paramount importance:

Battery Efficiency: Excessive heat can reduce the battery’s efficiency, leading to energy loss. Efficient thermal management ensures that the battery operates at its optimal temperature, maximizing energy efficiency.

Battery Life: Prolonged exposure to high temperatures can significantly reduce the lifespan of a battery. Proper thermal management helps maintain the battery within its ideal temperature range, extending its longevity.

Safety: Overheating batteries can pose safety risks, including the potential for thermal runaway and fires. Effective thermal management systems help prevent these hazards, ensuring the safety of both the vehicle and its occupants.

Performance: Temperature fluctuations can affect the performance of EV batteries, leading to reduced power output and slower acceleration. Maintaining consistent temperature levels through thermal management systems ensures peak performance.

Range: Temperature impacts the range of an electric vehicle. Cold weather can reduce range due to decreased battery efficiency, while extreme heat can lead to faster degradation. Thermal management helps mitigate these effects, providing a more predictable and consistent driving range.

Challenges in Thermal Management for EV Batteries

Managing the thermal environment of an EV battery pack presents unique challenges. These challenges include:

Non-Uniform Heat Generation: Different cells within a battery pack may generate heat at varying rates, making it challenging to maintain uniform temperatures.

Environmental Conditions: EVs operate in diverse climates, from extreme cold to scorching heat. Effective thermal management must adapt to these varying conditions.

Fast Charging: Rapid charging generates more heat, which must be dissipated quickly to prevent thermal issues. This requires efficient cooling systems.

Space Constraints: EV batteries are typically placed in confined spaces within the vehicle, limiting the available area for thermal management components.

Weight Considerations: Adding heavy thermal management systems can impact the vehicle’s overall weight and, subsequently, its efficiency and range.

Silicone Tubing: A Solution for Effective Thermal Management

To address the challenges of thermal management in EV batteries, manufacturers are turning to silicone tubing as a versatile and efficient solution. Silicone tubing offers several key advantages in managing the thermal environment of battery packs:

Heat Resistance: Silicone tubing is highly heat-resistant, making it suitable for applications where temperatures can vary significantly. It can withstand both high and low-temperature extremes, ensuring durability and reliability in various climates.

Flexibility: Silicone tubing is highly flexible, allowing it to conform to the shape and layout of the battery pack. This flexibility is essential for reaching all areas of the battery and providing even cooling or heating.

Insulation: Silicone tubing can act as an insulator, helping to maintain consistent temperatures within the battery pack. It can prevent heat transfer between cells, ensuring uniform thermal conditions.

Corrosion Resistance: Silicone is inherently resistant to corrosion, which is crucial in an environment where moisture and chemical exposure can occur.

Lightweight: Silicone tubing is lightweight, which is beneficial for EVs seeking to minimize additional weight to maximize efficiency and range.

Silicone Tubing Applications in EV Thermal Management

Coolant Circulation: Silicone tubing is often used to transport coolant within the battery pack. The coolant absorbs heat generated by the cells and circulates it to an external cooling system, where it can be dissipated efficiently. The flexibility of silicone tubing allows for intricate coolant pathways within the pack.

Insulation: Silicone tubing can be applied as an insulating layer around individual battery cells to maintain a stable temperature. This prevents localized overheating and thermal runaway events.

Ventilation Systems: Ventilation is crucial for dissipating heat from the battery pack. Silicone tubing can be used in conjunction with ventilation systems to direct airflow to specific areas of the pack that require cooling.

Thermal Coupling: Silicone tubing can be used to create thermal coupling between the battery cells and a heat exchanger or heat sink. This ensures effective heat transfer, helping to keep the battery at the desired temperature.

Electrical Insulation: Silicone tubing can also serve as electrical insulation in the battery pack, preventing short circuits and ensuring the safety of the electrical components.

Conclusion

Thermal management is a critical aspect of electric vehicle battery design, with profound implications for efficiency, performance, safety, and longevity. As electric vehicles continue to gain traction in the automotive industry, effective thermal management solutions become increasingly vital.

Silicone tubing stands out as a versatile and reliable choice for thermal management in EV batteries. Its heat resistance, flexibility, insulation properties, corrosion resistance, and lightweight nature make it an ideal material for a range of applications within the battery pack.

Silicone tubing in battery packs exemplifies the potential of this material to revolutionize thermal management in electric vehicles. As technology continues to evolve, we can expect further advancements in thermal management systems, with silicone tubing playing a central role in shaping the future of electric vehicle battery design.

In summary, silicone tubing is more than just a conduit for fluids; it is a key enabler of efficient, safe, and high-performance electric vehicles, helping drive us towards a cleaner and more sustainable future.

If you wish to talk about solutions with someone from our team phone us at 800-506-3924 or +1-215-526-2300,
e-mail info@newageindustries.com,
or use the Contact Us form below.

The post Harnessing Silicone Tubing for Effective Thermal Management in EV Batteries appeared first on NewAge Industries.

1.Proper Equipment Selection:

Choosing the right equipment for fluid transfer is fundamental to ensure the integrity of the process. Consider the following factors:

a. Material Compatibility: Select materials that are chemically compatible with the fluid being transferred to prevent contamination or adverse reactions. Also, be aware of reactions between materials that could compromise performance. Understanding the material compatibility between silicone and TPE (thermoplastic elastomer) tubing is crucial. By conducting appropriate compatibility studies, you can make informed decisions regarding the selection of silicone or TPE tubing for their specific application requirements.

b. Sterilizability: Use equipment that holds up to your chosen sterilization modality or understand effects that may impact the performance of a material or component.

c. Ease of Use: Opt for user-friendly equipment, facilitating the efficient and error-free fluid transfer.

2.Establishing Aseptic Techniques:

Maintaining sterility throughout the fluid transfer is critical to avoid microbial contamination. Adhere to these guidelines:

a. Clean Working Environment: To minimize the risk of contamination, perform fluid transfer operations in a designated clean area, such as a laminar flow hood or an ISO Class 5 cleanroom.

b. Personal Protective Equipment (PPE): Wear appropriate PPE, including gloves, lab coats, masks, and hairnets, to prevent the introduction of contaminants from personnel.

c. Disinfection: Thoroughly clean and disinfect all equipment and surfaces involved in fluid transfer, including tubing, connectors, and transfer vessels, using appropriate disinfectants.

3.Proper Handling and Storage:

To maintain the quality and viability of fluids during transfer, consider the following practices:

a. Temperature Control: To preserve their integrity, keep temperature-sensitive fluids within their specified temperature range during transfer and storage.

b. Minimize Exposure: Minimize exposure to air, light, and other environmental factors that may degrade the fluid’s quality. Use opaque tubing or cover transfer vessels to shield light-sensitive fluids. In addition, keeping your tubing and hose organized and off the floor using a Hose Holder reduces the potential for accidental contamination, as the floor is the dirtiest part of the clean room.

c. Minimize Shear Stress: Avoid excessive agitation or turbulence during fluid transfer to minimize shear stress, which can damage delicate cells or proteins. The best way to do that is to have smooth junctions using overmolding. Overmolding reduces the potential for shear stress and the likelihood of leaks and accidental contamination because the system is one unit versus multiple components with barbed junctions.

d. Moving From Room To Room: One place there is a lot of risk for contamination is when moving fluid from room to room. AdvantaPass provides a safe and easy way to move large volumes of liquid from one room to another without the risk of bin breakage or spillage.

4.Validation and Documentation:

Maintaining thorough documentation and validation of fluid transfer processes is crucial for regulatory compliance and process optimization:

a. Standard Operating Procedures (SOPs): Develop and follow SOPs for fluid transfer operations, including step-by-step instructions, safety guidelines, and quality checks.

b. Equipment Calibration: Regularly calibrate equipment, such as pumps and flow meters, to ensure accurate and precise fluid transfer.

c. Process Monitoring: Implement robust monitoring systems to track critical process parameters, such as flow rates, pressures, and temperatures, to ensure consistency and identify any deviations.

5.Training and Continuous Improvement:

Invest in training programs and foster a culture of continuous improvement to enhance fluid transfer practices:

a. Operator Training: Provide comprehensive training to personnel involved in fluid transfer, emphasizing aseptic techniques, equipment handling, and safety protocols.

b. Performance Analysis: Analyze process data, evaluate performance metrics, and conduct periodic audits to identify areas for improvement and implement corrective actions.

c. Knowledge Sharing: Encourage collaboration and knowledge sharing among team members to leverage collective expertise and stay updated with the latest advancements in fluid transfer technology.

In conclusion, implementing best practices in fluid transfer for bioprocessing is essential to ensure the process’s integrity, sterility, and efficiency. By selecting appropriate equipment, adhering to aseptic techniques, and focusing on proper handling, storage, validation, and training, bioprocessing facilities can minimize the risk of contamination, improve process outcomes, and maintain high-quality bioproducts. With continuous improvement and attention to detail, bioprocess operators can enhance their fluid transfer practices and contribute to the success of their bioprocessing operations.

If you wish to talk about solutions with someone from our team phone us at 800-506-3924 or +1-215-526-2300,
e-mail info@newageindustries.com,
or use the Contact Us form below.

The post Best Practices in Fluid Transfer for Bioprocessing appeared first on NewAge Industries.

Ever wondered how life-changing treatments such as vaccines, insulin, and gene therapies are created?

In this blog post, we provide a simplified overview of the intricate process behind harnessing the power of proteins and DNA to revolutionize healthcare – the process of making Biopharmaceuticals.

Biopharmaceuticals are medicines made from living organisms or their components, such as proteins or DNA. The process of creating biopharmaceuticals involves several steps. Here’s a simplified explanation of the process:

2. Cell Line Development: Once a promising candidate is identified, scientists create a cell line that can produce the desired biological molecule. This involves introducing the genetic material responsible for producing the molecule into a host cell, such as a bacterial or mammalian cell.

3. Cell Cultivation: The selected cell line is then grown in a controlled environment, such as a bioreactor or a culture vessel. The cells are provided with the necessary nutrients and conditions for growth, allowing them to multiply and produce the desired biological molecule.

4. Harvesting: When the cells have reached a sufficient density and have produced the desired amount of the biological molecule, they are harvested from the culture. This can involve separating the cells from the culture medium and other components.

5. Purification: The harvested material is then subjected to various purification steps to isolate the desired biological molecule from other impurities. This typically involves filtration, chromatography, and other techniques to remove unwanted substances and ensure the purity of the final product.

6. Formulation and Fill-Finish: After purification, the biopharmaceutical is formulated into its final dosage form, such as a liquid or lyophilized (freeze-dried) powder. It may undergo additional processing steps to enhance stability or improve delivery. The final product is then filled into appropriate containers, such as vials or syringes, and prepared for distribution.

7. Quality Control: Throughout the entire process, strict quality control measures are in place to ensure the safety, efficacy, and consistency of the biopharmaceutical. This involves rigorous testing and analysis at each stage to monitor the product’s characteristics and confirm compliance with regulatory standards.

8. Clinical Trials and Approval: Before a biopharmaceutical can be made available to the public, it typically undergoes rigorous testing in clinical trials to evaluate its safety and efficacy. If the results are positive, the regulatory authorities review the data and grant approval for the biopharmaceutical to be marketed and sold.

9. Manufacturing and Distribution: Once the biopharmaceutical receives regulatory approval, it can be manufactured on a larger scale. Specialized facilities are used to produce the biopharmaceutical in large quantities, following strict quality control protocols. The finished products are then distributed to healthcare providers, pharmacies, and patients.

It’s important to note that the biopharmaceutical process is complex, time-consuming, and highly regulated to ensure the safety and effectiveness of the medicines produced. The steps mentioned here provide a simplified overview, and in reality, each stage involves many detailed processes and considerations.

Click To Download Our Bioprocess Term Glossary

NewAge Industries makers of AdvantaPure have many fluid transfer solutions for your bioprocessing needs.

Click to learn more about our different products.

If you wish to talk about solutions with someone from our team
phone us at 800-506-3924 or 215-526-2300,
e-mail info@newageindustries.com,
or use the Contact Us form below.

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Single-use molded tubing assemblies are also made by injection molding. Our proprietary process combines extruded silicone tubing or braid-reinforced hose with liquid silicone to form molded connections in shapes such as wyes, tees, crosses, and reducers. Multiple connections can be incorporated into a single, finished part. AdvantaFlex tubing assemblies are made similarly.

Other types of molding processes for plastics and rubber include:

Extrusion Blow Molding –  Extrusion blow molding is a process that can create hollow parts quickly across a variety of large and small applications. The process starts with the formation of a long hollow tube of plastic called the parison. The parison is extruded downward until it extends past the bottom of the mold, the mold then closes upon the parison. At this stage of the process, air is introduced via a blow pin at the top of the part, or a needle in the middle of the part, inflating the plastic and pushing it to the surface of the mold. Air pressure is maintained for the part to maintain contact with the surface through the cooling cycle of the process. Extrusion blow molding is used to produce a wealth of items, including large containers, gas tanks, toys, and 55-gallon drums.

Injection Blow Molding – This process is a variation of extrusion blow molding where instead of extruding a parison, an injection molded preform is produced. Typically, the preforms will resemble test tubes and are injection molded first. Then in either the same machine or a different machine, they are transferred to the blow molding stage of the process. During which it is conditioned with either heating or cooling to the correct temperature to blow the preform into the shape of the desired molded part. Once it is properly conditioned, air is introduced at the neck of the part, blowing it out to the surface of the mold surfaces to form into shape. Once it takes the shape of the mold, pressure is maintained to allow good contact with the mold for proper cooling of the part. Injection blow molding is often used to make seamless bottles.

Compression Molding – Compression molding can be used to form parts from both thermoplastic and thermoset materials. The base material is loaded into the cavity of the mold. The mold is then closed, and equal pressure is applied across the part. At this point the material cures to form the shape of the intended part. Once cured the mold then opens and releases the part. Compression molding is utilized to rapidly produce plastic bottlecaps but is also used to make the soles for shoes.   

Rotational – Rotational molding is a polymer processing technique that creates seamless, hollow parts using a rotating metal mold and heat. A polymer in micro-pellet, powder, or liquid form is placed into a mold, which is then rotated on two or more axes. Conventional rotomolding machines use large ovens to heat the entire carriage assembly, whereas state-of-the-art machines allow for the mold to be heated directly. As the mold is heated, a melt pool forms at the lowest point of the mold. Each rotation through the melt pool deposits a new layer of polymer, gradually building up to the product’s target wall thickness. This process allows for unique parts to be produced without weld lines, in odd geometries, and at large product sizes. Rotational molding can be used for producing kayaks, water storage tanks, ice coolers, gasoline/diesel tanks, trash cans, and more.

Transfer Molding – Transfer molding is like injection molding in that the plastic or rubber material is put into a closed mold to form parts. It differs, however, in that a container placed above the mold or within the mold which material is first placed in and melted. Once melted, it is pushed into the mold using a plunger. Inserts such as wires or circuit boards can be placed in the mold before the plastic or rubber material is transferred, thereby encasing the inserts.

The extrusion process is referred to by some as extrusion molding, but here at NewAge we simply call it extrusion. No molds are used. Tubing is manufactured by forcing melted plastic or rubber through a die that forms the shape. The tubing runs through cooling water baths or heated cure towers to set its form.

Another process that sets plastic into a specific shape is heat forming. It’s a process that takes tubing or reinforced hose which has already been extruded and shapes it into a custom form by means of heat and custom fixtures. Shapes such as elbows, flared ends, and retractable coils are possible.

Learn more about our extrusion process, heat-formed shapes, or our AdvantaPure products.

If you have questions about the different types of molding or how it can help your project, phone us at 800-506-3924 or 215-526-2300, e-mailinfo@newageindustries.com, or use the Contact Us form below.

The post Types of Molding appeared first on NewAge Industries.

Several types of fluoropolymers are manufactured into tubing and fittings. While their general characteristics are similar, some properties vary depending on the formulation. The chart below provides a closer look at the types of fluoropolymer tubing available from NewAge Industries.

Other types of fluoropolymer materials include:

• PVDF (polyvinylidene fluoride)
• ETFE (ethylene tetrafluoroethylene)
• ECTFE (ethylene chlorotrifluoroethylene)
• PCTFE (polychlorotrifluoroethylene)

Fluoropolymers offer the lowest coefficient of friction of any solid material. The smooth surfaces of fluoropolymer tubing make it ideal for applications such as adhesive delivery, environmental sampling, and pure air and water systems.

Learn more about NewAge Industries’ fluoropolymer tubing and injection molded PFA compression fittings. In addition to straight tubing, we also offer formed & coiled parts in FEP and PFA tubing, corrugated FEP tubing (for increased bend radii) and convoluted PTFE tubing (for easier flush cleaning).

If you need fluropolymer tubing or have questions, phone us at 800-506-3924 or 215-526-2300, e-mail info@newageindustries.com, or use the Contact Us form below.

The post What Is A Fluoropolymer? appeared first on NewAge Industries.